Mode of Action of Isonicotinic Hydrazide

Isonicotinic Acid Hydrazide

Isonicotinic Acid Hydrazide in the Treatment of Lupus Vulgaris

Isonicotinic acid hydrazide (rimifon) in the treatment of tuberculosis.

Following reports on the effectiveness of isonicotinic acid hydrazide in the treatment of tuberculosis,’ a clinical trial was instituted at the San Angel Sanatorium in Mexico City. Beginning in March 1952, a series of 13 hospitalized and 12 ambulatory patients were started on therapy with Rlmifon* and the results evaluated at the end of a 90-day period. The hospitalized patients selected for st...

Charge Transfer Interactions between Isonicotinic Acid Hydrazide and Cupric Ions

The interaction of Cu2+ with isonicotinic acid hydrazide (INH) and some of its derivatives has been investigated by means of electron spin resonance, nuclear magnetic resonance, and optical absorption studies. It could be shown that an interaction exists between the metal ions and the hydrazine side chain in addition to the very weak interaction with the ring nitrogen. The results obtained indi...

Pyridoxine-responsive anemia conditioned by isonicotinic acid hydrazide.

S INCE THE FIRST report in 1956 of a patient with pyridoxine-responsive anemia, a number of other patients have been reported.”2 The red blood cells usually are hypochromic and microcytic but occasionally they may be macrocytic and accompanied by megaboblastic bone marrow maturation. It is unlikely that many of these patients have a simple dietary deficiency of pyridoxine, since barge doses of ...